New cembranoid diterpenes from the cultured octocoral Nephthea columnaris.
نویسندگان
چکیده
Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 1-3 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 1-4 against a panel of tumor cells is also described.
منابع مشابه
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عنوان ژورنال:
- Molecules
دوره 20 7 شماره
صفحات -
تاریخ انتشار 2015